Latest Research Papers
Inhibition of miR-125b-1-3p alleviates acute kidney injury and mitochondrial membrane potential loss by targeting GSTK1.
As a type of regulated necrosis driven by iron-dependent lipid peroxidation, ferroptosis critically contributes to acute kidney injury (AKI). Currently, whether miR-125b-1-3p is engaged in this pathological process remains unknown. Here, miR-125b-1-3p was upregulated in kidney tissues from an AKI model (GSE125305), in serum from a small exploratory cohort (15…
NAD and NADPH in Neuronal Injury and Degeneration.
The review focuses on novel targets recently identified in the mechanisms of neuronal death, and specifically in axonal degeneration. Depletion of NAD triggers various death pathways depending on the nature of the NAD degradation trigger. Wallerian degeneration (WD) of axons in the peripheral nervous system follows the specific mechanism activated…
CPT-TCPP polymeric nanoplatform for sonodynamic-chemotherapy synergistic tumor therapy through ferroptosis-apoptosis dual cell death reprogramming.
Traditional cancer therapies are constrained by tumor diversity, therapeutic resistance, and side effects, thereby necessitating the development of precise multimodal antitumor strategies. This work reports a relatively high-drug-loading polymeric nanoplatform, PSCT, for combined sonodynamic therapy and chemotherapy. Camptothecin (CPT) and tetracarboxyphenylporphyrin (TCPP) were covalently linked to a polymer and self-assembled…
Sustained Regression of Parotid Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma After Nutritional and Nutraceutical Intervention Without Chemoimmunotherapy: A Case Report.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) in the setting of Sjögren's syndrome (SS) is a well-recognized complication of chronic autoimmune salivary gland inflammation. Standard management options include radiotherapy, immunotherapy, and combination chemoimmunotherapy, with active surveillance reserved for stable, low-burden disease. The potential role of structured nutritional and…
Cell death pathways in the pathogenesis of depression: mechanisms and therapeutic implications.
Depression is a highly prevalent and disabling psychiatric disorder with a complex and incompletely understood pathophysiology. Increasing evidence implicates regulated cell death (RCD), including apoptosis, necroptosis, pyroptosis, and ferroptosis, in neuronal vulnerability, synaptic impairment, and circuit dysfunction associated with depression. This review provides a comprehensive overview of the current understanding…
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS-mediated ferroptosis.
Quiescent cancer cells (QCCs) drive tumor dormancy and recurrence through their resistance to conventional therapies. Furthermore, because QCCs rely on oxidative phosphorylation and maintain a fragile redox balance, we hypothesized that they harbor a targetable redox vulnerability. Here, we show that the mitochondria-targeted agent dequalinium chloride (DQ) selectively kills QCCs…
Innovative hydrogel systems for antioxidant and cardiac protection after myocardial infarction: addressing Ferrostatin-1 solubility and retention challenges.
Myocardial infarction (MI) triggers severe oxidative stress and ferroptosis, leading to progressive cardiomyocyte death and impaired cardiac function. Inhibiting ferroptosis in ischemic myocardium with Ferrostatin-1 (Fer-1) shows potential in reducing oxidative stress and preserving cardiac function after MI. To address the challenges of Fer-1's poor water solubility and low cardiac…
Targeting activated hepatic stellate cells through ferroptosis: phenethyl isothiocyanate attenuates CCl-induced liver fibrosis by regulating iron metabolism, redox homeostasis, and autophagy.
Phenethyl isothiocyanate (PEITC), a dietary compound from cruciferous vegetables, is known for its chemopreventive activity, but its effects on liver fibrosis remain largely unexplored. In this study, we show that PEITC administration attenuated carbon tetrachloride (CCl)-induced hepatic injury and fibrosis in mice, as evidenced by reduced collagen deposition, hydroxyproline content…
Bulk and single-cell transcriptomics identify tumor-specific epithelial PSAT1 as a ferroptosis-associated therapeutic target in cervical cancer.
Cervical cancer, the fourth most frequent malignancy in women worldwide, continues to be a major public health concern. Around 90% of high-grade cervical cancer cases are linked to infection with human papillomavirus (HPV). This phenotype, histologically, includes two major subtypes of cervical cancer: squamous cell carcinoma and adenocarcinoma. Drug resistance…
Metabolic vulnerabilities in multiple myeloma: targeting iron and amino acid metabolism to induce ferroptosis.
Could ferroptosis, a novel cell death pathway, offer a potential therapeutic strategy for multiple myeloma (MM)? Our previous research showed that ferroptosis is suppressed in MM patients, with varying sensitivities among MM cells. In this study, metabolomic analysis highlighted the pivotal role of amino acid metabolism, rather than lipid metabolism,…